Mitochondrial Metabolic Reprogramming Induced by Calorie Restriction
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چکیده
منابع مشابه
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in CR adaptation; however, the molecular details remain elusive. We developed and applied a quantitative mass spectrometry method to probe the liver mitochondrial acetyl-proteome during CR versus control diet in mice that were wild-type or lacked the protein deacetylase SIRT3. Quantification of 3,285 ace...
متن کاملCalorie restriction alters mitochondrial protein acetylation.
Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry scre...
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Mason, R. .I. (1982) in Lung Det9elopment: triological and Clinical Perspecrives (Farrell, P. M., ed.), vol. I , pp. 135-150, Academic Press, New York Mason, R. J. & Nellenboaen, J . (1982) Fed. Proc. Fed. Am. SOC. E.xp. Biol. 41, 1600 Okano. G. & Akino, T. (1978) Biochim. Biophj.s. Acta 528, 373 384 Oldenborg, V . & Van Golde, L. M. G . (19'76) Biochim. Biophys. Acta 441, 433442 Possmayer, F. ...
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Caloric restriction (CR) without malnutrition slows the aging process and extends lifespan in diverse species by unknown mechanisms. The inverse linear relationship between calorie intake and lifespan suggests that regulators of energy metabolism are important in the actions of CR. Studies in several species reveal tissue-specific changes in energy metabolism with CR and suggest that metabolic ...
متن کاملSkeletal muscle transcriptional coactivator PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction.
Calorie restriction (CR) is a dietary intervention that extends lifespan and healthspan in a variety of organisms. CR improves mitochondrial energy production, fuel oxidation, and reactive oxygen species (ROS) scavenging in skeletal muscle and other tissues, and these processes are thought to be critical to the benefits of CR. PGC-1α is a transcriptional coactivator that regulates mitochondrial...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2013
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2012.4866